For instance, DNA–binding nanoparticles could protect against sepsis-induced multi-organ injury in mice by scavenging DNA.479 STING activation could exacerbate sepsis-induced multi-organ injury by promoting cGAS- and IFN-dependent ferroptosis in macrophages.480 Here, we discuss the role of NA sensing in sepsis-induced dysfunction in lungs, liver, brain, heart, kidneys and gut. Here, IFNA1 is linked to Sepsis.