cGAS deficiency improves survival, reduces cytokines, alleviates leukopenia and organ injury in CLP-induced sepsis.455 Deletion of cGAS promotes macrophage M2 polarization via mtDNA-mTOR complex 1 pathway, thereby improving sepsis outcome.718 STING knockout in CLP mouse model suppresses inflammatory response, restores intestinal barrier dysfunction, inhibits microbial translocation and improves survival and hypothermia, while STING agonist exacerbates these pathological changes.518,719. Here, CGAS is linked to Decreased total leukocyte count.