In septic mice, cytoplasmic mtDNA accumulation in splenic DCs activates STING, leading to immunoparalysis with reduced costimulatory molecules, increased IL-10 and impaired T cell proliferation.466 Moreover, STING activates poly(ADP-Ribose)-polymerase 1 and poly(ADP-ribose) polymer, and triggers necrotic death of T cells in sepsis.467 STING also induces apoptosis in CD4+ T cells from LPS-treated mice.468. This evidence concerns the gene STING1 and Sepsis.