STING1 and cancer: For instance, correlation analysis of intratumoral STING transcript levels with overall survival for different cancers implicated high STING expression with better prognosis.610–612 Conversely, several other studies associated increased expression and activation of the STING pathway with tumor progression in different cancer entities.613–615 These observations illustrate a highly context-dependent role of NA sensing in the control of endogenous spontaneous tumorigenesis616 and likely represent a rich area for fundamental discoveries to come.