The role of the AIM2 inflammasome in influenza is recently reviewed by Australian researchers.302 Host DNA could be detected by AIM2 to induce protective immune response against IAV infection.303 IAV activates the AIM2 inflammasome, promotes host DNA release and inflammation in the lung, while AIM2 knockout reduces lung injury and improves survival without compromising viral clearance and adaptive immunity.304 IAV M2 and PB1-F2 proteins induce oxidization and cytosolic release of nDNA and mtDNA in mouse macrophages, initiating AIM2 inflammasome-dependent IL-1β production.234. This evidence concerns the gene AIM2 and influenza.