The activation of AIM2 inflammasome is mainly located in monocytes during COVID-19.379 Junqueira et al. found that SARS-CoV-2 uptake by monocytes triggers pyroptosis through AIM2 and NLRP3 inflammasomes, halting virus production.380 Furthermore, the plasma levels of pyroptotic makers (gasdermin D, interleukin-1 receptor antagonist and IL-18) are elevated in COVID-19 patients and correlate with disease severity.380 AIM2 inflammasome activation may be linked to lung fibrosis in COVID-19. The gene discussed is NLRP3; the disease is COVID-19.