STING1 and Sepsis: Activated STING is detected in PBMCs from patients with sepsis-induced ALI.488 In addition, the mtDNA-cGAS-STING-NLRP3 axis contributes to LPS-induced ALI.489 In particular, STING impedes lysosomal acidification and disturbs autophagic flux in macrophages via IFN, aggravating sepsis-induced ALI.488 In the context of AIM2 inflammasome activation, the expression of AIM2 in immune cells within the lungs increases during LPS-induced ALI.490 The activation of AIM2 inflammasome is triggered by NETs and induces alveolar macrophage pyroptosis.280