TLR7 and myocardial infarction: Upregulation of TLR7 expression could be seen in human and murine ischemic myocardium post MI.579 To be more specific, high expression of TLR7 is observed in cardiac infarct zone rather than remote non-infarct area of murine MI model.556 Furthermore, single-cell RNA sequencing demonstrated that TLR7 transcriptive levels in PBMCs are increased in AIM patients with plaque rupture.580 TLR7 is involved in acute cardiac ischemic injury and chronic remodeling.