Data on the development of synthetic agonists for NA sensors such as cGAS, STING, RIG-I, TLR3/7/8/9 and their efficacy in cancer immunotherapy have been extensively reviewed elsewhere.602 The notion that targeted activation of these sensors restricts the growth of transplanted tumors, sparks the questions, if their physiological activation exerts tumor-suppressive activities over a life time and thus acting tumor suppressive. The gene discussed is RIGI; the disease is neoplasm.