A study found that miRNA-146-5a levels increase during sepsis and are sensed by TLR7, promoting monocyte and neutrophil recruitment, blood-brain barrier disruption and encephalopathy in mice.505 The research group also discovered that plasma EVs from septic mice activate microglia and cerebral immune responses via TLR7 and MyD88 signaling.506. The gene discussed is MYD88; the disease is Sepsis.