A recent study by Mu et al. reported similar neuroprotective effects of the agonist JNJ-63533054 in the medial septum cholinergic neurons of an AD murine model, where JNJ-63533054 rescued Aβ1–42-induced neurotoxicity and apoptosis, and the overexpression of GPR139 in this cholinergic population rescued cognitive impairment and neuronal damage [55]. This evidence concerns the gene GPR139 and Cognitive impairment.