PRKN and pemphigus: Parkin protein can ubiquitinate a variety of substrates, recognizing and promoting the degradation of markedly damaged or over-accumulated proteins, thereby influencing inflammatory signaling pathways.27, 28 Bumiller-Bini et al. used microarray hybridization and multivariate logistic regression to systematically study the allele and genotype frequencies encoding all 12 mature cell death cascades in 227 patients with pemphigus foliaceous and 194 controls.