The polyprotein is cleaved into 3 structural proteins (E2, core, and E1) and 7 nonstructural proteins (NS2, p7, NS4A, NS3, NS5B, NS4B, and NS5A) through the action of both viral and host proteases.[4] The 21 kDa HCV core protein, the first viral protein expressed during infection, plays a critical role in particle assembly and various stages of the viral life cycle.[5] Current treatments for HCV include NS5A inhibitors, NS3/NS4A protease inhibitors, cyclophilin inhibitors, and nucleoside/nonnucleoside NS5B polymerase inhibitors. This evidence concerns the gene KRAS and infection.