In the liver, it is the primary cytokine responsible for significantly altering the synthesis of many APP.[56] As a multifunctional cytokine, IL-6 influences a variety of cellular activities, including proliferation, survival, apoptosis, and the regulation of inflammatory responses.[57] During hepatitis C infection, IL-6 production increases significantly in B cells alongside interferon-beta, following strong activation of toll-like receptors. This evidence concerns the gene APP and hepatitis C virus infection.