The knockout of lncRNA H19 in the liver of normal mice resulted in elevated blood glucose levels, impaired glucose tolerance, and upregulated expression of gluconeogenic genes.[14] Relevant investigation has also demonstrated the involvement of lncRNA H19 in the regulation of gluconeogenesis.[15] These findings suggest that lncRNA H19 plays a crucial role in lipid and glucose metabolism. This evidence concerns the gene H19 and Impaired glucose tolerance.