Irrespective of etiology, hepatic overexpression of lncRNA H19 significantly facilitates liver fibrosis, whereas ablation of lncRNA H19 confers protection against this pathological process.[16,17] Hepatic fibrosis is a reparative process characterized by excessive deposition of extracellular matrix (ECM) due to the activation of hepatic stellate cells (HSCs). This evidence concerns the gene H19 and Hepatic fibrosis.