A recent study has demonstrated that elevated expression of lncRNA H19 in various chronic liver diseases contributes to liver fibrosis by directly interacting with enhancer of zeste homolog 2, thereby facilitating the activation of HSCs.[18] The findings of this study suggest that lncRNA H19 is not only implicated in the pathogenesis of MAFLD but also plays a significant role in its progression. The gene discussed is H19; the disease is Hepatic fibrosis.