Studies have demonstrated that the Non-HDL-C/HDL-C ratio is more effective than LDL-C and Non-HDL-C in predicting atherosclerotic disease.[20] Additionally, it provides a more accurate prediction of insulin resistance and metabolic syndrome compared to the ApoB/ApoA1 ratio, likely due to disruptions in HDL-C levels.[7]. The gene discussed is APOA1; the disease is Insulin resistance.