BCHE and neurodegenerative disease: VCI, like AD, is a neurodegenerative disease characterized by progressive memory decline and cognitive loss.[125] With the advent of the aging society, the incidence of cognitive impairment is gradually increasing, and will become the main cause of death and disability in the elderly.[15] Although cholinesterase inhibitors and NMDA antagonists,[126] as well as the emerging targeted amyloid scavenger Lecanemab,[127] have brought new hope for countless patients with dementia, severe adverse effects and high price often make patients do not have satisfactory treatment results.