APOE and Alzheimer disease: A recent meta-analysis revealed that while age plays a crucial role in the association between APOE-e4 and Alzheimer disease, there is no significant gender-based variation observed in the overall association of APOE-e4 with Alzheimer disease.[15,16] The researchers conducted a comprehensive analysis revealing that the APOE gene exerts a crucial influence on individuals aged 55 to 70 years, especially among women who exhibit heightened vulnerability to Alzheimer disease during this specific age bracket.