ZRSR2 and metabolic dysfunction-associated steatohepatitis: In addition, an RNA-Seq dataset (Gene Expression Omnibus database [GEO], GSE126848) of liver samples from healthy donors and individuals with MASH, as well as quantitative PCR (qPCR) analyses of liver biopsy samples collected from MASH patients, further confirmed that expression of ZRSR2, the predominant minor intron splicing factor in humans, was suppressed in patients with MASH (Figure 1E, Supplemental Figure 1B, and Supplemental Table 1).