The database of the Rush Alzheimer’s Disease study by the ENCODE consortium (https://www.encodeproject.org/) [45,46] contains transcriptome and four epigenome data such as histone modifications (H3K27ac, H3K27me3, and H3K4me3) and CCCTC-binding factor (CTCF) binding site distribution from individuals in the “No Cognitive Impairment (NCI),” “Mild Cognitive Impairment (MCI),” and “Alzheimer’s Disease (AD)” groups that are available for unlimited public use (termed Rush AD database thereafter). This evidence concerns the gene CTCF and Cognitive impairment.