TRAK2 and Alzheimer disease: Herein, both sets of upregulated and downregulated genes in MCIMajor contained some previously reported AD risk-associated genes; in particular, the upregulated gene set contained CYP19A1, GSTM1, HSD11B1, IL10, MT-RNR1, PCK1, TRAK2, UBE2D1, and XBP1, whereas the downregulated gene set contained MT-ATP8 and NME8 [61].