The upregulated genes in both the N-A1 and N-A2 set contained AR, CBS, CLU, CYP19A1, DBH, GNA11, HLA-A, IQCK, MPO, MS4A4E, MX1, NLRP3, SDC2, TAP2, and ZFHX3 (S3d and S3e Tables), all of which have been reported to be AD risk-associated genes in recent studies [61,70–72]. Here, MS4A4E is linked to Alzheimer disease.