NLRP3 and Alzheimer disease: We identified CLU, SDC2, and ZFHX3 in both the CA1 and CA2 clusters, whereas DBH, GNA11, IQCK, MPO, and NLRP3 were identified in both the CB1 and CB2 clusters (S3d and S3e Tables), thereby suggesting that these AD risk genes are responsible for the differences in the features among the three AD subgroups [61,72].