Whereas, genes with lower expression levels in patients with AD in both the N-A1 and N-A2 set were enriched in GO terms for “negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator,” “negative regulation of DNA damage response, signal transduction by p53 class mediator,” and “coronary vasculature morphogenesis” (P-value <  10-3 and FDR <  0.5) (S3h and S3k Tables). This evidence concerns the gene TP53 and Alzheimer disease.