SPEN and Hepatic fibrosis: As a previous study reported the upregulation of hsa_circ_0072437 (PARP8), hsa_circ_0001147 (RBM39), hsa_circ_0047086 (ABHD3), hsa_circ_0010117 (SPEN) and hsa_circ_0005325 (UBA2) in hepatic fibrosis tissues [29], we examined their expression in liver tissues from control donors and hepatic fibrosis patients, and found that hsa_circ_0047086 (circAHBD3) showed highest expression (Fig 1A).