The pore-forming component of the hair cell MET channel is thought to be the transmembranechannel-like protein 1 (TMC1) protein (2, –4), and there are at least 50 reported point mutations (pathogenic variants) of the TMC1 gene causing human deafness (5), underscoring the key role of TMC1 in sound transduction. This evidence concerns the gene TMC1 and deafness.