EGFR and head and neck squamous cell carcinoma: The present study aims to determine whether tissue with native target expression can be used as a background to determine metastatic LN in patients with HNSCC infused with anti-epidermal growth factor receptor (EGFR) targeted imaging agents.<h4>Procedures</h4>Twenty-two patients infused with panitumumab-IRDye800 or cetuximab-IRDye800 prior to surgery were included.