MAPT and supranuclear palsy, progressive, 1: Alzheimer’s disease (AD) as the most common form of dementia is characterized by the aggregation of tau isoforms with both 3-repeat (3R) and 4-repeat (4R) binding domains, and corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) mainly by the 4R isoform [2].