MAPT and tauopathy: Similarly, dynamic tau-PET imaging using [18F]PI-2620 DVR highlighted significant sex-related differences (+ 7.9%, p < 0.0001), predominantly in the 3/4R-tauopathies cohort (+ 13.3%, p < 0.0001), while the other cohorts exhibit low (4R-tauopathies: 5.7%, p = 0.015; healthy controls: 9.3%, p = 0.012) or no (disease controls: −1.9%, p = 0.744) significant difference between both sexes (Fig. 2B).