It was found that FBP1 C129, R244 and D128 could form a pocket that interacted with the phosphate group of phosphorylated TERT S227 peptide, transferring the phosphoryl group of pS227 of TERT to FBP C129 while releasing dephosphorylated TERT, which could not be translocated to the nucleus, thus decreasing nuclear levels of TERT, telomerase activity, and telomere length, and promoting cancer cell senescence [58]. The gene discussed is TERT; the disease is cancer.