PKM and cholangiocarcinoma: Elevated expression of PKM2 has been reported in hepatocellular carcinoma [107], cholangiocarcinoma [108] and other tumors, and the driver genes of adrenocortical carcinoma, PRKAR-1A, CTNNB1, ZNRF3, TP53, CCNE1, and TERF2, were closely related to PKM2 [109].