DUSP3 and hypertensive disorder: The DUSP3 inhibitor also markedly attenuated the hypertension caused by d-alanine feeding in DAAO-TGTie2 mice; there was still a small but statistically significant increase in blood pressure in the DUSP3-treated d-alanine–fed DAAO-TGTie2 mice compared with the negative controls (Figure 7C).