SLC22A12 and Hyperinsulinemia: Moreover, we found a positive association between the TyG index, an indicator of hyperinsulinemia, and serum urate levels, which was synergistically augmented by a SNP with an eQTL effect on SLC22A12, whereas a rare LOF SNV in SLC22A12 tended to synergistically diminish the association, demonstrating the gene-environment interaction (Figure 5).