PRKAA1 and neoplasm: Indeed, our data suggest that, while AMPKα1 and AMPKα2 may have a shared set of downstream targets that are necessary for Treg cell function in the TME and the lung during viral pneumonia, isoform-specific activities may have divergent influences on Treg cell function, as evidenced by the dichotomous tumor burden relative to control mice observed in Prkaa1fl/flFoxp3YFP–Cre and Prkaa2fl/flFoxp3YFP–Cre mice.