Cluster 1 contained genes significantly upregulated in AMPKα1/α2–deficient tumor-infiltrating Treg cells and included genes encoding chemokines (Ccl2, Ccl7, Ccl8), modulators of lipid metabolism (Cd36, Pparg, Lpl, Abca1), and glycolytic enzymes (Hk2, Hk3). The gene discussed is PRKAA1; the disease is neoplasm.