Cluster 1 contained genes significantly upregulated in AMPKα1/α2–deficient tumor-infiltrating Treg cells and included genes encoding chemokines (Ccl2, Ccl7, Ccl8), modulators of lipid metabolism (Cd36, Pparg, Lpl, Abca1), and glycolytic enzymes (Hk2, Hk3). This evidence concerns the gene HK2 and neoplasm.