Considering the expression of Prkaa1 and Prkaa2 in control Treg cells of influenza-infected lungs (Supplemental Figure 7, A and B), as well as the compromised tissue-protective function of AMPKα1/α2–deficient Treg cells during viral pneumonia, these data suggest that AMPKα1 and AMPKα2 share redundant functions in this context. Here, PRKAA2 is linked to influenza.