To evaluate the actual effect of Norwogonin on osteoclast differentiation under RA conditions, as hypothesised, we first conducted the CCK‐8 assay to determine the viability of osteoclast precursor cells under a 48‐h OIM stimulation (with or without RANKL) in the presence of various concentrations of Norwogonin (80, 100, 120, 140, 160 μM). This evidence concerns the gene TNFSF11 and rheumatoid arthritis.