IL1B and rheumatoid arthritis: Since LPS is a classical RA‐mimicking agent that promotes the secretion of inflammatory factors, such as IL‐17A, TNF‐α and IL‐1β [56, 57], and ROS plays a pivotal role as a central mediator in inflammatory pathways and reactions [58], we proceeded to investigate the effects of LPS on the ROS scavenger system, along with unravelling the potential mechanisms by which Norwogonin impairs LPS‐induced osteoclast differentiation and function.