IL6 and neoplasm: Intriguingly, IL-6 and CXCL8 immunolabeling was localized along the tumor–lung interface of these metastases, a microanatomic region often spatially enriched for CAFs, suggesting that LFs may be contributing to this IL-6 and CXCL8 expression, given that dual labeling for tumor- or fibroblast cell–specific phenotype markers was also not performed in this study.