VEGFA and cancer: The potential of spheroids in this area is intriguing and inspiring, as it opens new possibilities for testing drugs that target hypoxic cells and understanding the adaptive mechanisms of cancer cells.70,72,73 In a recent study, endothelial cell culture on porous microfluidic channel surfaces was magnetically attached to tumor spheroids generated on a composite polymer-hydrogel microwell plate, which allowed the study of the pro-angiogenic endothelial cell organization and prevented the angiogenesis by inhibition of the VEGF pathway and the Notch signaling pathway.74