It is a widely accepted belief was that the tumorgenesis of ccRCC resulted from disorder of multiple pathway mainly including the dysregulation of von hippel-lindau/HIF protein signaling and PI3K/AKT/mTOR, the deletion of 3P chromosome and the defection of homologous recombination repair (21–24). This evidence concerns the gene AKT1 and nonpapillary renal cell carcinoma.