Specifically, they have observed that under the long-term influence of AngII, normal prostate cells can exhibit hypertrophy and hyperplasia and extracellular matrix (ECM) was more susceptible to degradation by the upregulation of MMP-2 and MMP-9, suggesting a potential role of RAS in the pathogenesis of prostate cancer (29). This evidence concerns the gene MMP2 and prostate cancer.