Additionally, the Keap1-Nrf2 system has been identified as a mediator between oxidative stress and cardiac dysfunction, suggesting that targeting Nrf2 and autophagy may hold promise for addressing laminopathy-induced cardiac dysfunction (Bhide et al., 2024; Yu and Xiao, 2021; Zang et al., 2020b). Here, NFE2L2 is linked to laminopathy.