Comparisons of CD80 expression in the M0 subpopulation between RA patients and HC showed that although RA patients expressed higher levels of CD80 in the Del and Mix groups, these levels were significantly lower than those observed in the controls (p values for Del and Mix were 0.00175 and 0.0106, respectively) (Figure 7). Here, MIXL1 is linked to rheumatoid arthritis.