Minor criteria include (i) fever greater than 38oC, (ii) an association with malignancy, inflammatory disease, pregnancy, or preceding infection or vaccination, (iii) response to corticosteroids or potassium iodide, and (iv) at least three out of four elevated inflammatory markers (ESR > 20 mm/hour, elevated CRP, WBC > 8000 cells/uL, or > 70% neutrophils). Drug-induced SS requires all five criteria that were developed by Walker and Cohen in 1996 [8]. This evidence concerns the gene CRP and cancer.