Conversely, the negative correlation between PRR13 and Th1 cells, which are known to enhance anti-tumor immune responses through the production of interferon-γ (IFN-γ) and other cytokines (Gunderson et al., 2020), suggests that PRR13 overexpression might suppress the function of these anti-tumor immune cells. The gene discussed is PRR13; the disease is neoplasm.