IFN-γ can also drive CD8+cells to differentiate into Tc1 cells (Mittrücker et al., 2014) and produce more pro-inflammatory molecules including IFN-γ, TNF-α, granzyme B and perforin (St Paul and Ohashi, 2020), which play a role in the initiation and development of colitis (Nancey et al., 2006; Westendorf et al., 2006). The gene discussed is IFNG; the disease is colitis.