Although based on transcriptional features, the risk stratification generated by this ensemble model also reflects adverse or favorable genomic aberrations including mutations in WT-related genes and segmental chromosome CNVs.TGFA was identified as the most important gene in the construction of random forest model, consistent with previous studies showing increased expression of TGFA in WT is correlated with tumor classification and clinical progression (53). This evidence concerns the gene TGFA and neoplasm.