DEG analysis indicated that compared to Scissor- tumor cells, Scissor+ tumor cells exhibited significantly higher expression of genes involved in metanephros (GDNF, KIF26B, EYA1, FGF2, HOXD11) and mesenchyme development (SIX2, HMGA2, PDGFC, WNT3A, GATA4), as well as semaphorin-plexin pathways (SEMA3D, SEMA3A, SEMA3E, PLXNA1), which are essential for regulating early fetal kidney morphogenesis (Figures 3D, E). The gene discussed is HMGA2; the disease is neoplasm.