A recent study showed that elevated expression of Wnt5a was associated with poor prognosis in non-small cell lung cancer (NSCLC) patients (35); Upregulation of the neuropeptide neurotrophin (NTS) is associated with poor prognosis in lung adenocarcinoma(LUAD) (36),There are relatively few studies on the prognosis of NTS and LUSC, and the correlation is not yet clear, our study shows that high NTS expression in LUSC is associated with better prognosis. The gene discussed is WNT5A; the disease is lung adenocarcinoma.