ACKR3 and cancer: Neurotensin receptor-1 (NTS1) is a G-protein coupled receptor that is being studied in various cancers, where neurotensin (NT) where oncogenic effects in tumors growth and metastatic spread (47, 48).The expression of NTS and its receptor holds potential as a predictive and prognostic marker for colorectal cancer in the postoperative selection of adjuvant therapy (49, 50), Our study Our study suggests that NTS could serve as a predictive and prognostic marker for LUSC.