Moreover, treatment of hepatocellular carcinoma (HCC)-bearing mice with IFN-α shifted TAM phenotypes from an M2-like to an inflammatory polarization, characterized by decreased expression of CD206 and arginase 1 (Arg1) and increased expression of inducible nitric oxide synthase (iNOS) (102). The gene discussed is IFNA2; the disease is hepatocellular carcinoma.