As demonstrated in several acute myeloid leukemia (AML) cell lines treated with a CIN-inducing monopolar spindle 1 (MPS1) kinase inhibitor, micronuclei generation, activation of cGAS/STING signaling, and induction of IFN-β are the consequences of chromosome mis-segregation (25). This evidence concerns the gene IFNB1 and acute myeloid leukemia.