As compared to the control group (SOD: 45.42 ± 1.31 U/mg prot; MDA: 6.69 ± 1.38 nmol/mg prot), a dramatic reduction of SOD activity (14.89 ± 2.09 U/mg prot) was detected in the HCD group (p < 0.001), while the MDA level (27.21 ± 2.65 nmol/mg prot) was significantly higher (p < 0.001; Figures 5C,D). The gene discussed is SOD1; the disease is heavy chain disease.