Therefore, RPS6KA2 may play a role in two ways: on the one hand, it may promote endothelial cell angiogenesis, and on the other hand, it may promote the progression of malignant epithelial cells by activating the KRAS signaling pathway; on the other hand, in diabetic patients, hyperglycemia and inflammation trigger endothelial dysfunction, which may eventually lead to vascular remodeling and renal damage (58). This evidence concerns the gene RPS6KA2 and Hyperglycemia.