Given the low expression of KIF21A and PIGH in ccRCC and the high expression of RPS6KA2, KIF21A and PIGH may act as tumor suppressor genes that promote NK cell activation in ccRCC, while RPS6KA2 may function as an oncogene that inhibits NK cell activation. Here, RPS6KA2 is linked to nonpapillary renal cell carcinoma.