The lncRNA hypoxia inducible factor 1 alpha-antisense RNA 2 (HIF1A-AS2) was first discovered in 1999 by Thrash-Bingham and Tartof, who identified a transcript that could bind complementarily with the 3’-untranslated region (UTR) of HIF1α mRNA in renal clear cell carcinoma (11). This evidence concerns the gene HIF1A and clear cell renal carcinoma.