Neonatal lupus erythematosus (NLE), first described by Bridge and Foley in 1954, is an autoimmune syndrome caused by the transplacental transmission of maternal autoantibodies, primarily anti-SSA/Ro and anti-SSB/La, and occasionally anti-U1RNP, which bind to fetal tissues (1–3). The gene discussed is CALR; the disease is neonatal lupus erythematosus.