TP53INP2 and neoplasm: Pachymic acid (PA) has been shown to disrupt tumor cell architecture and induce apoptosis in renal tumor cells via upregulation of tumor protein p53-inducible nuclear protein 2 (TP53INP2) and tumor necrosis factor receptor-associated factor 6 (TRAF6), alongside activation of pro-apoptotic pathways involving caspase-8, caspase-3, and PARP (Li et al., 2024).