Among the studies on blocking the progression of AP to SAP, Huang et al [27] observed that cyclooxygenase 2 (COX-2) inhibitors (parecoxib and celecoxib) reduced serum tumor necrosis factor–α and IL-6 levels in patients with AP, reducing the incidence of SAP by approximately half. This evidence concerns the gene PTGS2 and alkaline phosphatase measurement.