According to recent research findings, deactivation of Hippo pathway kinases results in nuclear translocation of YAP/TAZ protein and subsequent interaction with TEAD1-4 transcription factors, leading to enhanced activation of target genes such as Ctgf (connective tissue growth factor) and Ankrd1 (cardiac ankyrin repeat protein), which contribute to the exacerbation of hepatic fibrosis [8]. Here, CCN2 is linked to Hepatic fibrosis.