Here, using colocalization analysis, 4 shared genes (C11orf30, TSLP, STAT6, and SMAD3) between asthma and CRS, 12 shared loci (BCL2, CCDC26, TSBP1, CEBPE, IL1RL1, ALOX15, RBX1, IRF-AS1, BCL2A1, ATXN2, IL33 and LIN01221) between blood eosinophil count and CRS were colocalized. The gene discussed is SMAD3; the disease is congenital rubella syndrome.