This analysis identified 4 shared loci (C11orf30, TSLP, STAT6, and SMAD3) colocalized among asthma, CRS and CRSwNP, 7 shared loci (BCL2, CCDC26, TSBP1, CEBPE, IL1RL1, ALOX15, and RBX1) colocalized among blood eosinophil count, CRS and CRSwNP, 2 unique loci (IRF1-AS1 and BCL2A1) colocalized between blood eosinophil count and CRS, and 3 unique loci (ATXN2, IL33, and LINC01221) colocalized between blood eosinophil count and CRSwNP (Fig. 5, Table S7-S10 in Additional file 2). Here, SMAD3 is linked to chronic rhinosinusitis with nasal polyps.