MAPT and Alzheimer disease: An exploratory extension of this analysis to the pre-defined Braak-stage regions that capture tau progression [48] yielded consistent results for the centiloid-by-SAA-interaction across BraakI (β = 0.119, p = 0.0226, Fig. 3B), BraakIII/IV (β = 0.146, p = 0.008, Fig. 3C) and BraakV/VI ROIs (β = 0.144, p = 0.017, Fig. 3D), indicating that SAA-positivity-related aggravation of tau deposition in an AD context not confined to a particularly vulnerable brain region.