MAPT and Mental deterioration: This result remained consistent when additionally controlling for diagnosis (β = 0.132, p = 0.0246) or tau-PET in the temporal meta ROI (β = 0.153, p = 0.030), or when using annual change rates in the MMSE score as an alternative measure of cognitive decline (β=-0.194, p = 0.039, available for a subset of N = 247 individuals).