This was further substantiated by longitudinal tau-PET analyses, showing that αSyn SAA positivity at baseline was related to faster rates of Aβ-driven tau accumulation in AD typical brain regions, overall supporting the hypothesis that αSyn co-pathology exacerbates the Aβ-driven formation of AD-type neurofibrillary tau pathology. The gene discussed is MAPT; the disease is Alzheimer disease.