Supporting this view, we found a significant interaction effect between amyloid-PET centiloid levels and SAA positivity on tau-PET SUVRs in the temporal meta-ROI that captures AD-typical tau accumulation, controlling for age, sex and study site (β = 0.147, puncorrected=0.006, pFDR−corrected=0.010). The gene discussed is MAPT; the disease is Alzheimer disease.