RRM2B and myelodysplastic syndrome: MDS has been linked to mutations in 8 genes, including thymidine kinase 2 (TK2), deoxyguanosine kinase (DGUOK), polymerase gamma (POLG), ATP-dependent and GTP-dependent succinyl coenzyme A synthetase ligases (SUCLA2 and SUCLG1), MPV17, mitochondrial twinkle helicase, and the cytoplasmic p53-inducible small subunit of ribonucleotide reductase (RRM2B), have been implicated in the pathogenesis of MDS [5, 6].