Incorporating novel, more specific biomarkers like dipeptidyl peptidase 3 (DPP3) and functional cytokine responses into frameworks like the Phoenix Score can significantly improve the early identification and management of pediatric sepsis, enabling a more precise and effective approach to care.8,9 Integrating novel and more specific biomarkers into the Phoenix Sepsis Score enhances its predictive capability. This evidence concerns the gene DPP3 and Sepsis.