Staining of ICC, Pdgfrα + , and glial cells using anti-c-Kit, Pdgfrα, and Gfap antibodies showed a slight yet significant increase in the density of these cell populations in Piezo1ΔSMC compared to Piezo1WT muscularis (Fig. 6C–E; Supp. Here, PDGFRA is linked to intrahepatic cholangiocarcinoma.