TP53 and glioblastoma: Liu et al. [85] found that Avasimibe induced mitochondria-dependent apoptosis in glioblastoma cells by arresting the cell cycle at the G0/G1 and G2/M phases, which was mediated through the regulation of the p53/p21, p53/GADD45A, and Aurora A/PLK1 signaling pathways.