In WHO CNS5 classification, glioblastoma is referred to the astrocytic glioma characterized by isocitrate dehydrogenase (IDH)-wild type and H3-wild type and exhibits one or more features, including microvascular proliferation, necrosis, telomerase reverse transcriptase (TERT) promoter mutation, epidermal growth factor receptor (EGFR) gene amplification, and +7/−10 chromosome copy-number changes [1]. This evidence concerns the gene TERT and glioblastoma.