In glioblastoma tissue, m6A machinery proteins, including METTL3, METTL14, WTAP, FTO, ALKBH5, YTHDF1, YTHDF2, YTHDF3, HNRNPC, etc. are significantly upregulated compared to normal brain tissue [134–136]. The gene discussed is ALKBH5; the disease is glioblastoma.