In a rat model of cerebral hemorrhage, MSC-derived exosomes have been found to promote neurogenesis, vascular remodeling, and myelin regeneration, significantly improving the rats’ behavioral and cognitive abilities.79 Li provided an explanation for the angiogenic capacity of bMSC-derived exosomes from the perspective of the chemokine CXCR4.80 Exosomes from bMSCs with high expression of the chemokine receptor CXCR4 promote the proliferation, angiogenesis, and anti-apoptotic effects of microvascular endothelial cells in stroke rats through the Wnt-3a/β-catenin pathway. This evidence concerns the gene CXCR4 and stroke disorder.