SOST and chronic kidney disease: Moreover, SOST also exerts regulatory effects on numerous other organs.50 For example, a lack of SOST affects the production of B lymphocytes and bone marrow cells, along with other changes within the bone marrow cavity that may impact hematopoiesis.51,52 Additionally, patients with chronic kidney disease exhibit elevated levels of SOST in their serum.53 In the brain, SOST advances the progression of AD through this pathway.