Microsomal prostaglandin E synthase-1 (mPGES-1) is a PGE synthase that couples with cyclooxygenase-2 (COX-2) and plays a pivotal role in the synthesis of PGE2 under pathological conditions such as inflammation.178 Brain inflammation similarly poses a threat to neuronal health, impairing the processing of afferent signals and the transmission of efferent signals.179,180 Therefore, alleviating inflammation may have a beneficial impact on the entire skeletal interoception system. This evidence concerns the gene PTGS2 and brain inflammatory disease.