Research indicates that the activation of the WNT/β-catenin signaling pathway has neuroprotective effects against amyloid-beta (Aβ) peptide toxicity, and it is also involved in Tau phosphorylation and the processes of learning and memory.54 The accumulation of Aβ plaques and the aggregation of Tau protein are considered two core characteristics of AD. This evidence concerns the gene MAPT and Alzheimer disease.