The serine/threonine protein kinase RIPK4 was also overexpressed, while genes downregulated in ATRX altered tumours included the p53-dependent G2M cell cycle regulator RPRM and the GTP-binding gene DRG2 – the latter gene also implicated in G2M cell cycle checkpoint control (Fig. 7C)42. The gene discussed is TP53; the disease is neoplasm.