Paired E169 tumours had a high number of shared SNVs (n = 3134) including mutations in TERT and BCOR; however, the number of SNVs doubled in the post-CVD (n = 12607) tumour including mutations in TP53, RPL5 and POLE (DNA Polymerase Epsilon) (Fig. 8B). The gene discussed is POLE; the disease is neoplasm.