Other chemokines, such as CXCL13 and CCL5, are also expressed by stem-immunity hubs, which involve interactions between myeloid cells (e.g., CXCL10+ macrophages, mature regulatory DCs) and T cells (CD8+, T-regs), and are linked to favorable outcomes with PD-1 blockade therapy.33 Detailed signal analysis suggested that unresponsive patients had higher tumor infiltration with specific TAMs. The gene discussed is CD8A; the disease is neoplasm.