The 1997-version ACR classification criterion has been canonically used for SLE diagnosis,86,87 with the classification indexes used being malar rash, discoid rash, photosensitivity, oral ulcers, non-erosive arthritis, pleuritis or pericarditis, renal disorder, neurological disorder, hematological syndrome, immunological evidence, and positive ANA. Here, BTG3 is linked to Oral ulcer.