These include, e.g., SLE-specific genetic risk factors such as the IL19 risk allele associated with a 2.3-fold increased risk of developing myocardial infarction and stroke among SLE carriers due to enhanced levels of IL10 and aPL antibodies,358 physiological risk factors such as male gender,359 advanced age,359–361 and postmenopausal status,360,361 lifestyle risk factors such as tobacco smoking,362 and medical risk factors such as hypertension,360 hypercholesterolemia, diabetes mellitus, and the associated medical interventions. The gene discussed is IL10; the disease is systemic lupus erythematosus.