For instance, hydralazine (a vasodilator) and procainamide (an anti-arrhythmic agent) can trigger SLE via forming neutrophil extracellular trap (NET)261,262 that can function as the auto-antigens due to DNA, histones and neutrophil proteins it contains.263 Excessive secretion of pro-inflammatory cytokines such as IFNα (used for treating Hepatitis B/C) aggravates SLE.264–266. The gene discussed is IFNA1; the disease is systemic lupus erythematosus.