IL1R1 and infection: Indeed, IL-1R-deficient mice show high susceptibility to C. albicans, indicated by rapid weight loss and approximately 1000-fold elevated fungal titers in the kidneys and brain, but not in the spleen or liver, three days post-infection with 105 CFU C. albicans (Fig. 1B, C), when mice had to be euthanized to prevent undue suffering.