Among the top 5 Ub E3 enzymes found enriched in BTZ-resistant cells, TRIM24 (tripartite motif 24) belongs to a family of E3 ligases that have been involved in multiple cellular processes such as intracellular signaling, apoptosis, protein quality control, autophagy, carcinogenesis, being their dysregulation associated to the development of multiple diseases including cancer [26–28]. Here, TRIM24 is linked to cancer.