CASC3 and mantle cell lymphoma: To further support the activity and specificity of the dTRIM24/BTZ combination in an in vivo setting, we developed two immunocompetent xenograft models of MCL derived from ZBRTRIM24 WT and ZBRTRIM24 KO cell lines using the chick embryo chorioallantoic membrane (CAM) method (Fig. 6) [31].