Fig 4B further shows a positive correlation between the level of ADCP and 5D3-CP33 concentrations ranging from 0.15 nM to 1 μ M in U937/PC3-PIP co-cultures, revealing that 5D3-CP33 can induce cancer-cell phagocytosis at concentrations as low as 150 pM. Like 5D3-CP33, the ch5D3 construct demonstrated selective phagocytosis by U937 cells exclusively in the presence of PSMA-positive cells, with no activation observed in PSMA-negative controls (Fig 4C). To provide visual confirmation of flow cytometry data, we imaged ADCP in analyzed cell mixtures by confocal microscopy (S2 Fig). The gene discussed is CYP3A4; the disease is cancer.